WAPMET® Tablets

Metronidazole Tablets

For Veterinary Use Only

COMPOSITION

WAPMET® 250

Each tablet contains:

Metronidazole ........................................ 250 mg

Excipients ............................................. q.s.

WAPMET® 500

Each tablet contains:

Metronidazole ........................................ 500 mg

Excipients ............................................. q.s.

PHARMACEUTICAL FORM

Scored oral tablets.

TARGET SPECIES

• Dogs

• Cats

INDICATIONS

WAPMET® Tablets are indicated for the treatment of infections caused by susceptible anaerobic bacteria and protozoa.

Recommended for:

• Acute and chronic diarrhea

• Hemorrhagic gastroenteritis

• Colitis

• Inflammatory bowel disease (adjunct therapy)

• Giardia infections

• Clostridial enteritis

• Anaerobic oral infections

• Dental infections

• Periodontal disease

• Deep bite wounds

• Skin and soft tissue infections involving anaerobic bacteria

Treatment should be based on bacterial culture and antimicrobial susceptibility testing whenever possible.

SPECTRUM OF ACTIVITY

Effective against susceptible strains of:

• Clostridium spp.

• Bacteroides spp.

• Fusobacterium spp.

• Peptostreptococcus spp.

• Helicobacter spp.

• Giardia duodenalis

• Trichomonas spp.

PHARMACOLOGICAL PROPERTIES

Metronidazole is a nitroimidazole antimicrobial with antibacterial and antiprotozoal activity.

It acts by disrupting microbial DNA synthesis, leading to cell death. It is highly active against obligate anaerobic bacteria and protozoal organisms.

DOSAGE AND ADMINISTRATION

Administer orally.

Dogs and Cats

10–25 mg/kg body weight

Twice daily

Treatment duration:

• Gastrointestinal infections: 5–7 days

• Giardia: 5–7 days

• Anaerobic infections: 7–10 days

• Chronic enteropathies: According to veterinary judgment.

CONTRAINDICATIONS

Do not use in animals with known hypersensitivity to metronidazole.

Use with caution in animals with severe hepatic disease.

SPECIAL WARNINGS

Avoid prolonged treatment unless clearly indicated.

Use antimicrobials responsibly to minimize antimicrobial resistance.

ADVERSE REACTIONS

Occasionally:

• Vomiting

• Diarrhea

• Reduced appetite

• Hypersalivation

Rarely:

• Ataxia

• Tremors

• Neurological signs

• Seizures following overdose or prolonged treatment

Treatment should be discontinued if neurological signs develop.

USE DURING PREGNANCY AND LACTATION

Use only according to the benefit-risk assessment by the attending veterinarian.

DRUG INTERACTIONS

Use with caution when administered together with:

• Phenobarbital

• Cimetidine

• Warfarin-type anticoagulants

OVERDOSE

May cause:

• Ataxia

• Tremors

• Depression

• Seizures

Treatment is symptomatic and supportive.

STORAGE

Store below 25°C.

Protect from moisture and direct sunlight.

Store in the original package.

SHELF LIFE

36 months.

PRESENTATION

Available strengths:

• WAPMET® 250

• WAPMET® 500

Pack sizes:

• 10 tablets

• 20 tablets

• 100 tablets