CALPHOVIA® Injection

Calcium, Magnesium, Phosphorus & Vitamin D₃ Injection

Sterile Solution for Injection
500 mL

For Veterinary Use Only

COMPOSITION

Each 100 mL contains:

• Calcium Gluconate ........................................ 22 g

• Magnesium Hypophosphite ......................... 4.2 g

• Calcium Glycerophosphate .......................... 1.8 g

• Vitamin D₃ (Cholecalciferol) ......................... 100,000 IU

Excipients .................................................. q.s. to 100 mL

PHARMACEUTICAL FORM

Sterile clear solution for intravenous or subcutaneous injection.

TARGET SPECIES

• Dairy Cattle

• Beef Cattle

• Buffaloes

• Sheep

• Goats

• Camels

INDICATIONS

CALPHOVIA® is indicated for the prevention and treatment of calcium, magnesium and phosphorus deficiencies, including:

• Milk Fever (Parturient Paresis)

• Hypocalcaemia

• Subclinical Hypocalcaemia

• Grass Tetany (Hypomagnesaemia)

• Downer Cow Syndrome

• Periparturient Metabolic Disorders

• Pregnancy Toxaemia (Supportive Therapy)

• Weakness after Calving

• Poor Muscle Function

• Reduced Feed Intake

• Recovery after Transport or Stress

PHARMACOLOGICAL PROPERTIES

CALPHOVIA® provides a balanced combination of calcium, magnesium, phosphorus and Vitamin D₃.

Calcium

• Restores normal blood calcium concentration

• Improves neuromuscular function

• Supports cardiac contraction

• Essential for milk production

Magnesium

• Prevents neuromuscular excitability

• Supports enzyme activity

• Essential in the prevention of grass tetany

Phosphorus

• Supports energy metabolism

• Improves appetite

• Enhances muscle performance

• Promotes recovery

Vitamin D₃

• Enhances intestinal calcium absorption

• Improves calcium and phosphorus utilization

• Supports skeletal health

DOSAGE AND ADMINISTRATION

Administer by slow intravenous injection or subcutaneous injection.

Adult Cattle & Buffaloes

250–500 mL

Camels

250–500 mL

Calves

100–250 mL

Sheep & Goats

50–100 mL

Treatment may be repeated after 12–24 hours if required according to the veterinarian's assessment.

CONTRAINDICATIONS

Do not use in animals with:

• Hypercalcaemia

• Severe renal impairment

• Known hypersensitivity to any component of the formulation

SPECIAL WARNINGS

• Warm the solution to approximately body temperature before administration.

• Intravenous injection must be administered slowly while monitoring heart rate.

• Rapid intravenous administration may result in cardiac arrhythmias or cardiac arrest.

• Use aseptic injection techniques.

ADVERSE REACTIONS

Occasionally:

• Mild swelling at the injection site

• Transient discomfort

Rarely:

• Cardiac arrhythmias following excessively rapid IV administration

• Allergic reactions

USE DURING PREGNANCY AND LACTATION

Safe for use during pregnancy and lactation when administered according to veterinary recommendations.

Particularly recommended around calving and kidding in animals at risk of metabolic disorders.

DRUG INTERACTIONS

Do not administer simultaneously with:

• Digitalis glycosides

• Solutions containing incompatible phosphates

• Strong alkaline injectable preparations

Consult compatibility data before mixing with other injectable products.

OVERDOSE

Excessive administration may cause:

• Hypercalcaemia

• Bradycardia

• Cardiac arrhythmias

• Muscle weakness

Treatment should be discontinued immediately and supportive therapy instituted if overdose occurs.

WITHDRAWAL PERIOD

Meat: Zero days*

Milk: Zero days*

*Subject to local regulatory requirements.

STORAGE

Store below 25°C.

Protect from direct sunlight.

Do not freeze.

Keep the vial in the original carton.

SHELF LIFE

• 36 months before opening.

• Use within 28 days after first broaching (subject to stability studies).

PRESENTATION

Available pack sizes:

• 100 mL

• 250 mL

• 500 mL